(4,2-disubstituted-thiazol-5-yl)amine compounds as pde7...

Details (4,2-disubstituted-thiazol-5-yl)amine compounds as pde7... (4,2-disubstituted-thiazol-5-yl)amine compounds as pde7...

C - Chemistry, Metallurgy

07

D

C07D 277/42 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2480679

A compound selected from those of formula (I), wherein R1a, R1b, R2, R3 are as defined in the description, and optionally, its optical isomers, N-oxide, and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same are useful as specific inhibitors of phosphosdiesterase-7 (PDE-7).

La présente invention concerne un composé choisi parmi ceux représentés par la formule générale (I), et éventuellement ses isomères optiques, son N-oxyde, et certains de ses sels d'addition avec un acide ou une base pharmaceutiquement admis. Dans cette formule, les groupes R¿1a?, R¿1b?, R¿2? et R¿3? sont tels que définis dans la description. L'invention concerne également des produits médicinaux contenant les mêmes. Ces composés conviennent comme inhibiteurs spécifiques de la phosphosdiestérase-7 (PDE-7).

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