4-(2'-pyridylamino)phenylacetic acid derivatives

Details 4-(2'-pyridylamino)phenylacetic acid derivatives 4-(2'-pyridylamino)phenylacetic acid derivatives

C - Chemistry, Metallurgy

07

D

260/296, 260/297

C07D 213/74 (2006.01) C07D 213/79 (2006.01)

Patent

CA 1122601

4-(2'-PYRIDYLAMINO)PHENYLACETIC ACID DERIVATIVES Abstract of the Disclosure The invention relates to novel 4-(2-pyridylamino)- phenylacetic acid derivatives of the formula: Image wherein R1 is hydrogen, a halogen, a lower alkyl having 1 to 3 carbon atoms, or nitro, R2 is hydrogen, a halogen, or a lower alkyl having 1 to 3 carbon atoms, R3 is hydrogen, a halogen, or a lower alkyl having 1 to 3 carbon atoms, R4 is hydrogen or a lower alkyl having 1 to 3 carbon atoms, R5 is hydrogen or -CH2CH2OR6 wherein R6 is a lower alkyl having 2 or 3 carbon atoms and being substituted with 1 or 2 hydroxy groups, provided that R1 or R2 is not 4-halogen, or pharmaceutically acceptable salts thereof, and a process for the prepara- tion thereof. These compounds have excellent anti- inflammatory and analgesic activities with an extremely weak ulcerogenicity in the gastrointestinal tract. Some of the compounds have superior inhibitory activity against chronic inflammation mediated by cellular immunity.

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