C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/211, 260/266
C07D 417/06 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) C07D 277/14 (2006.01) C07D 277/60 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 471/10 (2006.01)
Patent
CA 2040489
This invention relates to compounds of the formula (see formula I) where R1 and R2 are independently hydrogen or loweralkyl or R1 and R2 taken together with the carbon atom to which they are attached form a spiro-fused cycloalkane of 5 to 8 carbons; R3 and R4 are independently hydrogen or loweralkyl or R3 and R4 taken together with the carbon atom to which they are attached form a spiro-fused cycloalkane of 5 to 8 carbons; R5 and R6 taken together with the nitrogen atom to which they are attached are (see formulas II, III, IV and V) (see formulas VI, VII, VIII, IX and X) where X in each occurrence is independently hydrogen, halogen, loweralkyl, hydroxy, nitro, amino, cyano, trifluoromethyl or methoxy: and m is 0, 1 or 2; the pharmaceutically acceptable acid addition salts thereof and where applicable the optical and geometrical isomers and racemic mixtures thereof. The compounds of this invention are useful as analgesic and antihypertensive agents.
Aventis Pharmaceuticals Inc.
Bereskin & Parr
Hoechst-Roussel Pharmaceuticals Inc.
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