4-(3,5-dicyanophenoxy) pyrazole derivatives for use as...

Details 4-(3,5-dicyanophenoxy) pyrazole derivatives for use as... 4-(3,5-dicyanophenoxy) pyrazole derivatives for use as...

C - Chemistry, Metallurgy

07

D

C07D 231/18 (2006.01) A61K 31/415 (2006.01) A61P 31/14 (2006.01) A61P 31/18 (2006.01) C07C 45/00 (2006.01) C07C 45/63 (2006.01) C07C 49/293 (2006.01) C07C 49/327 (2006.01) C07C 255/54 (2006.01)

Patent

CA 2496315

This invention relates to the pyrazole derivatives of formula (I) and pharmaceutically acceptable salt, solvate or derivatives thereof, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. The compounds of the invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors, thereof. Reverse transcriptase is implicated in the infectious lifecycle of Human Immunodeficiency Virus (HIV). Compounds which interfere with the function of this enzyme have shown utility in the treatment of conditions caused by HIV and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).

L'invention concerne des dérivés de pyrazole de formule (I) et leurs sels, solvates ou dérivés de ces derniers, pharmaceutiquement acceptables. Elle concerne également leur utilisation en médecine, des compositions les contenant, des procédés pour leur préparation et des intermédiaires utilisés dans lesdits procédés. Les composés selon l'invention se lient à la transcriptase inverse et constituent des modulateurs, notamment des inhibiteurs, de cette dernière. La transcriptase inverse est impliquée dans le cycle infectieux du virus de l'immunodéficience humaine (VIH). Les composés perturbant la fonction de cette enzyme se sont avérés utiles pour le traitement d'états provoqués par le VIH et des rétrovirus génétiquement apparentés, tels que le syndrome d'immunodéficience acquise (SIDA).

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