4(3h)-quinazolinone derivatives, process for production...

Details 4(3h)-quinazolinone derivatives, process for production... 4(3h)-quinazolinone derivatives, process for production...

C - Chemistry, Metallurgy

07

D

260/254

C07D 239/91 (2006.01) C07D 401/12 (2006.01)

Patent

CA 1167442

ABSTRACT OF THE DISCLOSURE The present invention relates to novel 4(3H)-quinazolinone compounds which are useful as hypotensive agents for the treatment of hypertensive diseases. The compounds have the formula Image wherein R1 and R3, independently from each other, represent a lower alkyl group; R2 represents a lower alkoxycarbonyl group; Q represents a phenyl group or a substituted phenyl group substituted by at least one member selected from the group consisting of halogen atoms, lower alkyl groups, lower alkoxy groups, di(lower)- alkylamino groups, a methylenedioxy group, a trifluoromethyl group, a hydroxyl group, and a nitro group; R4 represents a hydrogen atom or a lower alkyl group; R5 represents a member selected from the group consisting of a hydrogen atom, lower alkyl groups, lower halogenoalkyl groups, lower alkenyl groups, (lower)alkoxy-(lower)- alkyl groups, hydroxy(lower)alkyl groups, (lower)alkylthio(lower)- alkyl groups, (lower)alkylsulfinyl(lower)alkyl groups, (lower)- alkylsulfonyl(lower)alkyl groups, di(lower)alkylamino(lower)alkyl groups, a benzyl group, a phenethyl group, pyridyl(lower)alkyl groups, furfuryl groups, a phenyl group, and substituted phenyl groups substituted by a member selected from the group consisting of halogen atoms, lower alkyl groups, and lower alkoxy groups; and Z1 and Z2, independently from each other, represent an oxygen or sulfur atom; and acid addition salts thereof.

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