4-{4-[({3-tert-butyl-1-[3-(hydroxymethyl)...

Details 4-{4-[({3-tert-butyl-1-[3-(hydroxymethyl)... 4-{4-[({3-tert-butyl-1-[3-(hydroxymethyl)...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4439 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2673041

The compound 4-{4-[({3-tert-Butyl-1-[3-(hydroxymethyl) phenyl]-1H-pyrazol- 5-yl} carbamoyl)amino]-3-fluorophenoxy}-N-methylpyridine-2-carboxamide and alternative forms thereof (e.g., salts, solvates, hydrates, prodrugs, polymorphs and metabolites); pharmaceutical compositions which contain them; and methods for treating cancer using them. (I)

L'invention concerne un composé 4- {4- [ ( {3- tert- Butyl- 1- [3- (hydroxymethyl) phenyl]-1H- pyrazol- 5- yl} carbamoyl)amino]- 3- fluorophenoxy}- N- methylpyridine- 2- carboxamide et des formes alternatives de celui-ci (par exemple, des sels, des solvats, des hydrates, des promédicaments, des polymorphes et des métabolites); des compositions pharmaceutiques comprenant le composé et les formes alternatives de celui-ci; et des méthodes pour traiter un cancer au moyen de ce composé et des formes alternatives de celui-ci. (I)

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