4-¬4-¬4-(4-hydroxyphenyl)-1- piperazinyl|phenyl|-5-methyl-3h...

Details 4-¬4-¬4-(4-hydroxyphenyl)-1- piperazinyl|phenyl|-5-methyl-3h... 4-¬4-¬4-(4-hydroxyphenyl)-1- piperazinyl|phenyl|-5-methyl-3h...

C - Chemistry, Metallurgy

07

D

C07D 403/10 (2006.01) A61K 31/495 (2006.01) C07D 249/12 (2006.01)

Patent

CA 2076257

JAB 826 ABSTRACT 4-[4-[4-(4-HYDROXYPHENYL)-1-PIPERAZINYL]PHENYL]-5-METHYL- 3H-1,2,4-TRIAZOL-3-ONE 2-[2-(4-chlorophenyl)-2-(hydroxy or oxo)ethyl]-2,4-dihydro4-[4-[4-(4-hydroxy- phenyl)-l-piperazinyl]phenyl]-5-methyl-3H-1,2,4-triazol-3-one having the formula (I), Image wherein X represents C=O or CHOH, for use as 5-lipoxygenase inhibitors. Pharmaceutical compositions, processes for preparing said compounds and compositions; and a method of treating leukotriene mediated diseases.

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