4-(4-alkoxy-3-hydroxyphenyl)-2-pyrrolidone derivatives as...

Details 4-(4-alkoxy-3-hydroxyphenyl)-2-pyrrolidone derivatives as... 4-(4-alkoxy-3-hydroxyphenyl)-2-pyrrolidone derivatives as...

C - Chemistry, Metallurgy

07

D

C07D 417/02 (2006.01) A61K 31/4015 (2006.01) A61K 31/4439 (2006.01) A61P 25/00 (2006.01) C07D 207/26 (2006.01) C07D 207/27 (2006.01) C07D 401/02 (2006.01) C07D 401/12 (2006.01) C07D 403/02 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/02 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2463469

Selective PDE4 inhibition is achieved by 4-(substituted-phenyl)-2- pyrrolidinone compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds like rolipram and show selectivity with regard to inhibition of other classes of PDEs. The compounds of the present invention are of formula (I), wherein R1, R2 and R3 are as defined herein.

Selon l'invention, l'inhibition sélective de la PDE4 (phosphodiestérase 4) est obtenue au moyen de composés 4-(phényle substitué)-2-pyrrolidone. Ces composés présentent une inhibition de la PDE4 améliorée en comparaison avec des composés de type rolipram, et présentent également une sélectivité en ce qui concerne l'inhibition d'autres classes de PDE. Lesdits composés sont représentés par la formule (I) dans laquelle R?1¿, R?2¿, et R?3 ¿ont la signification indiquée dans la description.

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