C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2623646
The present invention relates to a ZD6474 monohydrate, to processes for the preparation of a ZD6474 monohydrate, to pharmaceutical compositions comprising a ZD6474 monohydrate as the active ingredient, to the use of a ZD6474 monohydrate in the manufacture of medicaments for use in the production of antiangiogenic and/or vascular permeability reducing effects in warm-blooded animals such as humans, and to the use of a ZD6474 monohydrate in methods for the treatment of disease states associated with angiogenesis and/or increased vascular permeability, such as cancer, in warm-blooded animals such as humans.
La présente invention concerne un monohydrate ZD6474, des procédés de préparation de ce monohydrate ZD6474, des compositions pharmaceutiques comprenant ce monohydrate en tant que principe actif, l'utilisation de ce monohydrate dans la fabrication de médicaments destinés à induire des effets antiangiogéniques et/ou réduisant la perméabilité vasculaire chez un animal à sang chaud tel que l'être humain; l'invention concerne en outre l'utilisation d'un monohydrate ZD6474 dans le cadre de procédés destinés à traiter des pathologies associées à l'angiogenèse et/ou à la perméabilité vasculaire accrue, tel le cancer, chez un animal à sang chaud tel que l'être humain.
Booth Rebecca Jane
Meyrick Brian Roger
Patel Zakariya
Storey Richard Anthony
Astrazeneca Ab
Fetherstonhaugh & Co.
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