4,4-(disubstituted)piperidine derivatives with ccr3 antagonism

Details 4,4-(disubstituted)piperidine derivatives with ccr3 antagonism 4,4-(disubstituted)piperidine derivatives with ccr3 antagonism

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61K 31/4709 (2006.01) A61K 31/517 (2006.01) A61P 1/00 (2006.01) A61P 11/02 (2006.01) A61P 11/06 (2006.01) A61P 17/00 (2006.01) A61P 17/04 (2006.01) A61P 27/14 (2006.01) A61P 31/18 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 487/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2483504

It is intended to provide low-molecular weight compounds having an activity of inhibiting the binding of a CCR3 ligand to CCR3 on a target cell, i.e., CCR3 antagonists. Namely, 4,4-disubstituted piperidine derivatives represented by the following general formula (I), pharmaceutically acceptable acid addition salts thereof or pharmaceutically acceptable C1-6 alkyl adducts thereof and medicinal compositions having effects of treating and/or preventing diseases in which CCR3 participates such as asthma and allergic nephritis which contain the same as the active ingredient.

Cette invention concerne des composés à faible poids moléculaire dont l'activité inhibe la liaison du ligand CCR3 à CCR3 sur une cellule cible, c'est-à-dire des antagonistes de CCR3. Il s'agit de dérivés de pipéridine 4,4 disubstitués représentés par la formule générale (I) suivante, des sels ou des adduits alkyle C¿1-6 ?pharmaceutiquement acceptables de ces composés et des compositions médicales les renfermant, qui ont une action thérapeutique ou préventive sur des maladies impliquant CCR3 telles que l'asthme ou la néphrite allergique.

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