4-(4-(imidazol-4-yl)pyrimidin-2-ylamino) benzamides as cdk...

Details 4-(4-(imidazol-4-yl)pyrimidin-2-ylamino) benzamides as cdk... 4-(4-(imidazol-4-yl)pyrimidin-2-ylamino) benzamides as cdk...

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2589793

Compounds of the formula: (I): wherein variable groups are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described are processes for their preparation and their use as medicaments, particularly medicaments for producing a cell cycle inhibitory (anti-cell-proliferation) effect in a warm-blooded animal, such as man.

La présente invention concerne des composés de formule : (I): dans laquelle des groupes variables sont tels que définis dans la description ; l~invention décrit des sels pharmaceutiquement acceptables et des esters hydrolysables in vivo . L~invention décrit également des procédés pour leur préparation et leur utilisation en tant que médicaments, en particulier des médicaments destinés à induire un effet d~inhibition du cycle cellulaire (anti-prolifération cellulaire) chez un animal à sang chaud, tel que l~être humain.

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