C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/08 (2006.01) A61K 31/18 (2006.01)
Patent
CA 2196064
Methanesulfonamides are structurally depicted by formula (I), or its pharmacologically acceptable salts where R3 is a C1-7 alkyl substituted with C3-7 cycloalkyl, or a C1-10 alkyl substituted with one to eight fluorine atoms, one to three hydroxy, one to three C1-5 acyloxy or one to three C1-4 alkoxy substituents. These compounds are useful as Class III antiarrhythmic agents and are stable against rapid metabolism. Methods for treating cardiac arrhythmias with the compounds of formula (I) as well as compositions thereof are also described.
Méthanesulfonamides de la formule (I), ou leurs sels pharmaceutiquement acceptables. Dans cette formule, R¿3? et un C¿1-7? alkyle substitué par un C¿3-7? cycloalkyle, ou un C¿1-10? alkyle substitué par 1 à 8 atomes de fluore, 1 à 3 substituants hydroxy, 1 à 3 substituants C¿1-5? acyloxy ou 1 à 3 substituants de C¿1-4? alcoxy. Ces composés se révèlent utiles comme agents antiarhythmiques de la classe III et se révèlent stables par rapport à un métabolisme rapide. L'invention porte également sur des méthodes de traitement des arhythmies cardiaques à l'aide de composés de la formule (I) ainsi que de compositions issues de ces composés.
Gibson J. Kenneth
Hester Jackson B. Jr.
Macrae & Co.
Pharmacia & Upjohn Company
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