C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/296
C07D 213/40 (2006.01)
Patent
CA 1161440
ABSTRACT OF THE DISCLOSURE Disclosed and claimed are a cardiac composition and a method for increasing cardiac contractility using an effective amount of a cardiotonic 4-[4-(or 3)-AcNH-phenyl]- 2-R2-3-R3-5-R5-6-R6-pyridine (I) or pharmaceutieally-accept- able salt thereof, where R2 is hydrogen, methyl, ethyl or hydroxyl, R6 is hydrogen, methyl or ethyl, R3 and R5 are each hydrogen or methyl, and Ac is hydrogen, hydroxyacetyl, acetoxyacetyl, .alpha.-hydroxypropionyl, .alpha.-acetoxypropionyl, methyoxyacetyl, 2-butenoyl or carbamyl or when NHAc is attached to the 4-position of the phenyl ring Ac also is formyl, n-propanoyl, 2,2-dimethyl-n-propanoyl or 3-car- boxypropanoyl or when NHAc is attached to the 3-position of the phenyl ring Ac also is acetyl. Novel compounds shown and claimed are 4-[4-(or 3)-Ac'NH-phenyl]-2-R2-3-R3-5-R5-6- R6-pyridines (II) or pharmaceutically-acceptable acid- addition salts thereof, where R2, R3, R5 and R6 are defined as above for I and Ac' is hydroxyacetyl, acetoxyacetyl, .alpha.- hydroxypropanoyl, .alpha.-acetoxypropionyl, methoxyaeetyl, 2- butenoyl or carbamyl or where Ac'NH is attached to the 4- position of the phenyl ring Ac' also is formyl, n-propanoyl, 2,2-dimethyl-n-propanoyl or 3-carboxypropanoyl. Also disclosed and claimed is the process for preparing said novel compounds (II).
378281
Lesher George Y.
Page Donald F.
Fetherstonhaugh & Co.
Sanofi-Synthelabo
Sterling Drug Inc.
LandOfFree
4-[4(or 3)-acylaminophenyl]pyridines, their preparation and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 4-[4(or 3)-acylaminophenyl]pyridines, their preparation and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4-[4(or 3)-acylaminophenyl]pyridines, their preparation and... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-561676