4,5,6,11-tetrahydrobenzo [6,7] -cycloocta [1,2-b]...

C - Chemistry – Metallurgy – 07 – D

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C07D 495/18 (2006.01) A61K 31/40 (2006.01)

Patent

CA 2017911

64680-550 4,5,6,11-TETRAHYDROBENZO[6,7]CYCLOOCTA [1,2-b]THIOPHEN-6,11-IMINES AND 6,11-DIHYROBENZO[6,7]CYCLOOCTA[1,2-b] THIOPHEN-6,11-IMINES Abstract The present invention relates to compounds of the formula Image wherein the broken line represents a saturated or an olefinic bond, R1 and R4 are each hydrogen or C1 to C6 alkyl, and R2 and R3 are each hydrogen, C1 to C6 alkyl, halogen, C1 to C6 alkoxy or C1 to C6 alkylthio, and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing the same, methods of preparing the foregoing compounds, and to novel intermediates in the preparation of the foregoing compounds. These compounds are useful as agents in the prevention of neuronal damage in the brain following cerebral ischemia and during the progression of Alzheimer's disease and also as anticonvulsants.

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