4,5,6,7-tetrahydroindazole derivatives as antitumor agents

Details 4,5,6,7-tetrahydroindazole derivatives as antitumor agents 4,5,6,7-tetrahydroindazole derivatives as antitumor agents

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/416 (2006.01) A61P 35/00 (2006.01) C07D 231/56 (2006.01)

Patent

CA 2372429

Compounds which are 4,5,6,7-tetrahydroindazole derivative formula (I), wherein the dotted line (x) represents a single or double bond; n is 0 or 1; R1, R2 and R3 have the meanings reported in the description; Ra, R'a, Rb, R'b, Rc, R'c have the meanings reported in the description, also comprising that Ra and Rb together and/or Ra and Rc together form a N-alkyl-piperydinyl ring with 1 to 6 carbon atoms in the alkyl chain or a phenyl ring; or pharmaceutically acceptable salts thereof, are useful for treating cell proliferative disorders and Alzheimer's disease.

L'invention concerne des composés qui sont des dérivés de 4,5,6,7-tétrahydroindazole représentés par la formule (I), dans laquelle la ligne pointillée (x) représente une liaison simple ou double; n représente 0 ou 1; R¿1?, R¿2? et R¿3? ont les notations mentionnées dans la description; Ra, R'a, Rb, R'b, Rc, R'c ont les notations mentionnées dans la description, et comprennent également que Ra et Rb et/ou Ra et Rc forment ensemble un noyau N-alkyl-pipérydinyle possédant de 1 à 6 atomes de carbone dans la chaîne alkylée ou un noyau phényle; ou des sels pharmaceutiquement acceptables de ces composés, qui sont utiles pour traiter des troubles de prolifération cellulaire et la maladie d'Alzheimer.

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