C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/231, 260/273
C07D 513/04 (2006.01) A61K 31/44 (2006.01)
Patent
CA 1337201
The present invention relates to novel compounds of the following formula: Image I individual isomers and pharmaceutically acceptable acid addition salts thereof, wherein R1 is hydrogen, alkyl or phenyl-lower alkyl, in which the phenyl group may be substituted with halogen, lower alkyl or lower alkoxy; R2 is alkyl, alkenyl, alkynyl, branched or unbranched, with 1-6 carbon atoms inclusive, which group may be optionally substituted with fluoro, hydroxy or phenyl optionally substituted with halogen, trifluoromethyl, lower alkyl, hydroxy or lower alkoxy; R3 and R4 are the same or different, and each represents hydrogen, alkyl (1-6 C-atoms), cycloalkyl (3-6 C-atoms), phenyl optionally substituted with halogen trifluoromethyl, lower alkyl, hydroxy or lower alkoxy, or phenyl-lower alkyl, inwhich the phenyl group may be substituted with halogen, trifluoromethyl, lower alkyl, hydroxy or lower alkoxy. The invention moreover relates to methods for the preparation of the compounds of formula 1, to novel intermediates, to pharmaceutical compositions containing same and to methods for the treatment of disorders, caused by malfunction of the acetylcholine (AcCh) or muscarinic system, by administering a non-toxic effective amount of a compound of formula I. The present invention relates to novel compounds of the following formula: Image I individual isomers and pharmaceutically acceptable acid addition salts thereof, wherein R1 is hydrogen, alkyl or phenyl-lower alkyl, in which the phenyl group may be substituted with halogen, lower alkyl or lower alkoxy; R2 is alkyl, alkenyl, alkynyl, branched or unbranched, with 1-6 carbon atoms inclusive, which group may be optionally substituted with fluoro, hydroxy or phenyl optionally substituted with halogen, trifluoromethyl, lower alkyl, hydroxy or lower alkoxy; R3 and R4 are the same or different, and each represents hydrogen, alkyl (1-6 C-atoms), cycloalkyl (3-6 C-atoms), phenyl optionally substituted with halogen trifluoromethyl, lower alkyl, hydroxy or lower alkoxy, or phenyl-lower alkyl, inwhich the phenyl group may be substituted with halogen, trifluoromethyl, lower alkyl, hydroxy or lower alkoxy. The invention moreover relates to methods for the preparation of the compounds of formula I, to novel intermediates, to pharmaceutical compositions containing same and to methods for the treatment of disorders, caused by malfunction of the acetylcholine (AcCh) or muscarinic system, by administering a non-toxic effective amount of a compound of formula I.
593449
Falch Erik
Krogsgaard-Larsen Povl
Pedersen Henrik
H. Lundbeck A/s
Perley-Robertson Hill & Mcdougall
LandOfFree
4,5,6,7-tetrahydroisothiazolo [4,5-c] pyridine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 4,5,6,7-tetrahydroisothiazolo [4,5-c] pyridine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4,5,6,7-tetrahydroisothiazolo [4,5-c] pyridine derivatives will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1305439