4,5,6 and 7-indole and indoline derivatives, their...

C - Chemistry – Metallurgy – 07 – D

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C07D 405/14 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) C07D 209/20 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/12 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2335711

A substituted 4-, 5-, 6-, and 7-indole or indoline derivative of Formula (I) wherein A is a group having formula (IIA), (IIB), (IIC) wherein X, U, Y, R3 to R12, Z, W, n and m are as defined above. The compounds are potent serotonin reuptake inhibitors and have 5-HT1A receptor antagonistic activity.

L'invention concerne un dérivé de 4-, 5-, 6-, et 7-indole ou d'indoline substitué de formule (I), dans laquelle A représente un groupe de formule (IIA), (IIB), (IIC), dans laquelle X, U, Y, R?3¿ à R?12¿, Z, W, n et m sont tels que définis ci-dessus. Les composés de cette invention sont de puissants inhibiteurs du recaptage de la sérotonine, et présentent une action antagoniste du récepteur 5-HT¿1A?.

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