4(5) - acetyl-2-methylimidazole process

Details 4(5) - acetyl-2-methylimidazole process 4(5) - acetyl-2-methylimidazole process

C - Chemistry, Metallurgy

07

D

260/314

C07D 233/64 (2006.01) C07D 233/54 (2006.01)

Patent

CA 1194489

ABSTRACT OF THE DISCLOSURE Process for making a valuable intermediate, from 2- methylimidazole-4(5)-carboxaldehyde, the 1-position of which is protected by a benzyl group which may be unsubstituted or sub- stituted. The process comprises a Grignard reaction followed by deblocking and oxidation, or by oxidation then deblocking. 4(5)- Acetyl-2-methylimidazole is particularly useful for the preparation of 2-guanidino-4-(2-methyl-4(5)-imidazolyl)thiazole, a histamine H2 antagonist of value in the treatment of gastric hyperacidity and peptic ulcers.

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