4- (5- (aminomethyl) -indole-1-ylmethyl) -benzamide...

Details 4- (5- (aminomethyl) -indole-1-ylmethyl) -benzamide... 4- (5- (aminomethyl) -indole-1-ylmethyl) -benzamide...

C - Chemistry, Metallurgy

07

D

C07D 209/08 (2006.01) A61K 31/4045 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) A61P 25/30 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2558030

The present invention relates to compounds of formulae (I) and (II) useful as opioid receptor antagonists for the treatment of obesity, wherein p is 0, 1, or 2; y is 0, 1, or 2; and z is 0, 1, or 2; X1 is CH2, CH, or N; to form a indolinyl, indolyl, or benzimidazole ring respectively and including applicable double bonds and/or hydrogen atoms; X2 is CH or N; R1 to R7, R3', p, y, and z are as defined in the claims.

L'invention concerne des composés représentés par les formules (I) et (II), qui sont utiles comme antagonistes des récepteurs opioïdes pour traiter l'obésité. Dans la formule, p représente 0, 1 ou 2 ; y représente 0, 1 ou 2 ; et z représente 0, 1 ou 2 ; X¿1? représente CH¿2?, CH ou N, pour former un noyau indolinyle, indolyle ou benzimidazole, respectivement, et comprend des doubles liaisons et/ou des atomes d'hydrogène utilisables ; X¿2? représente CH ou N ; R?1¿ à R?7¿, R?3'¿, p, y et z sont tels que définis dans les revendications.

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