4-(5- and 7-) benzoylindolin-2-ones

Details 4-(5- and 7-) benzoylindolin-2-ones 4-(5- and 7-) benzoylindolin-2-ones

C - Chemistry, Metallurgy

07

D

260/320, 260/306

C07D 405/10 (2006.01) C07D 209/34 (2006.01) C07D 317/54 (2006.01)

Patent

CA 1103679

Abstract of the Disclosure Novel 4-(5- and 7-) benzoylindolin-2-ones are described having the formula Image wherein R is hydrogen or lower alkyl, R2 is hydrogen, fluorine, chlorine, bromine, iodine or lower alkoxy, Z is hydrogen or SCH3, and X and Y are the same or different and represent hydrogen atoms or lower alkyl, lower alkoxy, fluorine, chlorine, bromine, iodine, nitro or trifluoromethyl groups, or together form a lower alkylenodioxy group. The compounds are prepared from corresponding aminobenzophenones, istatins, or indolin-2- ones. The compounds are precursors in the production of 2- amino-3-(5- and 6-) benzophenylacetic acids, esters, alkali metal salts and alkaline earth metal salts, which latter compounds exhibit pharmacological properties.

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