4,5-azolo-oxindoles

Details 4,5-azolo-oxindoles 4,5-azolo-oxindoles

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/404 (2006.01) A61K 31/4178 (2006.01) A61K 31/4188 (2006.01) A61K 31/424 (2006.01) A61K 31/429 (2006.01) A61P 35/00 (2006.01) C07D 403/06 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2354852

Novel 4,5-azolo-oxindoles having formula (I), wherein R1, R2, Y, Z and a have the meaning indicated in the specification, inhibit cyclin-dependent kinases (CDKs), in particular CDK2 and are useful in the treatment or control of cell proliferative disorders, in particular cancer.

L'invention concerne de nouveaux 4,5-azolo-oxindoles représentés par la formule (I) dans laquelle R<1>, R<2>, Y, Z et a ont la signification indiquée dans la demande, inhibent des kinases dépendantes des cyclines (CDK), notamment CDK2, et s'utilisent dans le traitement ou la lutte contre des troubles à prolifération de cellules, notamment le cancer.

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