4,5-bisphenyl-2-sulphur containing imidazole compounds

Details 4,5-bisphenyl-2-sulphur containing imidazole compounds 4,5-bisphenyl-2-sulphur containing imidazole compounds

C - Chemistry, Metallurgy

07

D

260/305, 260/314

C07D 233/84 (2006.01) C07D 233/88 (2006.01) C07D 405/02 (2006.01)

Patent

CA 1177836

ABSTRACT OF THE DISCLOSURE This invention provides a compound of the formula Image (I) in which Ar1 and Ar2, which may be the same or different, each represents a phenyl radical, unsubstituted or substituted by one or more of the same or different substituents selected from a halo- gen atoms, alkyl radicals containing 1 to 4 carbon atoms, alkoxy radicals containing 1 to 4 carbon atoms and dialkylamino radicals containing 2 to 6 carbon atoms; provided that both of the sub- stituents represented by Ar1 and Ar2 are not unsubstituted phenyl groups, R1 represents a hydrogen atom or an alkyl radical having 1 to 4 carbon atoms, n represents 0, 1 or 2, and Z represents an alkyl radical having 1 to 6 carbon atoms having additionally one or two of the same or different functional groups selected from hydroxy groups, alkoxy radicals containing 1 to 4 carbon atoms, alkylenedioxy radicals containing 2 to 4 carbon atoms, acyloxy radicals containing 1 to 4 carbon atoms, and alkoxycarbonyl radi- cals containing 2 to 5 carbon atoms, alkenyl containing 2 to 4 carbon atoms which may be substituted with hydroxy; or alkynyl containing 2 to 4 carbon atoms and which may be substituted with hydroxy, there being no more than one alkoxycarbonyl radical pre- sent and the total number of carbon atoms in Z being at least 2, or a pharmaceutically acceptable salt thereof. These compounds have anti-inflammatory and antiallergic activity.

328095

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