4,5-deoxymaytansinoids, their production and use

Details 4,5-deoxymaytansinoids, their production and use 4,5-deoxymaytansinoids, their production and use

C - Chemistry, Metallurgy

07

D

260/237.1, 260/2

C07D 498/08 (2006.01)

Patent

CA 1160629

Abstract of the Disclosure This invention relates to 4,5-deoxymaytansinoid compounds represented by the formula Image wherein X is a hydrogen atom or an alkyl or acyl group, Y is a hydrogen or chlorine atom, and R is a hydrogen atom or a carboxylic acid-derived acyl group, and methods of producing the same. The compounds are useful as antitumor, antiprotozoal and antifungal agents.

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