4,5-di-substituted 2-oxazolealkanoic acids, esters and...

Details 4,5-di-substituted 2-oxazolealkanoic acids, esters and... 4,5-di-substituted 2-oxazolealkanoic acids, esters and...

C - Chemistry, Metallurgy

07

D

260/311, 260/279

C07D 413/04 (2006.01) C07D 263/42 (2006.01)

Patent

CA 1084058

ABSTRACT OF THE DISCLOSURE This invention relates to novel and therapeutically valuable compounds which are useful as drugs for the treatment of arteriosclerosis with lipid metabolism disorder. They can be administered orally when prepared with a suitable and conventional carrier or adjuvant. The compounds are of the formula: Image (I) wherein R represents a phenyl group, a mono- or di-substituted phenyl group (in which the substituents are selected from the group consisting of a halogen atom, a methyl group and a nitro group) or a pyridyl group; R1 represents an ethyl groups each of R2 and R3 represents a hydrogen atom or a methyl group; n represents 0 or 1; and R4 represents a hydrogen atom, an alkyl group having 1 to 2 carbon atoms or an alkali metal atom. Hypolipidemic action is one of the excellent pharmacological properties possessed by the compounds. The pharmaceutical pre- parations can take any conventional form such as tablets, capsules, granules, powders or injectable solutions.

256902

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