4,5-diaryl oxazole derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 263/32 (2006.01) A61K 31/42 (2006.01) A61K 31/445 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2227442

Heterocyclic compounds of formula (I), wherein R1 is carboxy or protected carboxy, R2 is aryl which may have suitable substituent(s), R3 is aryl which may have suitable substituent(s), R4 is hydrogen, lower alkyl, hydroxy or aryl, A1 is lower alkylene, (a) is (b), etc., -A3- is (c), etc. and n is 0 or 1, and pharmaceutically acceptable salts thereof which are useful as a medicament.

La présente invention concerne des composés hétérocycliques représentés par la formule générale (I) dans laquelle R?1¿ est carboxy ou carboxy protégé, R?2¿ est un aryle pouvant avoir un ou plusieurs substituants appropriés, R?3¿ est un aryle pouvant avoir un ou plusieurs substituants, R?4¿ est hydrogène, alkyle inférieur, hydroxy ou aryle, A?1¿ est alkylène inférieur, le groupe représenté par la formule particulière (a) a une structure représentée par la formule particulière (b), etc., -A?3¿- est représenté par la formule particulière (c), etc., et n vaut 0 ou 1. L'invention concerne également des sels de ces composés, admis en pharmacie, et utiles comme médicaments.

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