4,5-diaryloxazole compounds with prostaglandin 12 (pg12)...

Details 4,5-diaryloxazole compounds with prostaglandin 12 (pg12)... 4,5-diaryloxazole compounds with prostaglandin 12 (pg12)...

C - Chemistry, Metallurgy

07

D

C07D 413/04 (2006.01) A61K 31/422 (2006.01) A61P 9/08 (2006.01)

Patent

CA 2383329

Heterocyclic compounds of formula (I) wherein R1 is carboxy or protected carboxy, R2 is aryl which may have substituent(s), R3 is aryl which may have substituent(s), X is oxygen or a pair of hydrogen and R5 (wherein R5 is hydroxy or protected hydroxy), and A1 and A2 are each independently lower alkylene and pharmaceutically acceptable salts thereof which are useful as a medicament.

L'invention porte: sur des composés hétérocycliques de formule (I) dans laquelle R?1¿ est carboxy où carboxy protégé, R?2¿ est aryle facultativement substitué, R?3¿ est aryle facultativement substitué, X est oxygène où une paire d'hydrogène et R?5¿ (R?5¿ étant hydroxy où hydroxy protégé), et A?1¿ et A?2¿ sont chacun indépendamment alkylène inférieur, et sur leurs sels pharmacocompatibles qui peuvent s'utiliser comme médicaments.

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