4,5-dihydro-¬1h|-benz¬g|indazole-3-carboxylic acid derivatives

Details 4,5-dihydro-¬1h|-benz¬g|indazole-3-carboxylic acid derivatives 4,5-dihydro-¬1h|-benz¬g|indazole-3-carboxylic acid derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/505 (2006.01) C07D 239/34 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2296037

4,5-Dihydro-[1H]-benz[g]indazole-3-carboxylic acid derivatives represented by general formula (I) or their salts, which have excellent antagonism to endothelin receptors and are useful as preventives or remedies for hypertension, angina pectoris, myocardial infarct, brain infarction, cerebrovascular contraction, renal insufficiency, liver function disorder, arteriosclerosis, post-PTCA reconstriction, etc., wherein Ar represents optionally substituted aryl; and R1 represents hydrogen, optionally substituted lower alkyl, optionally substituted aryl, optionally substituted cycloalkyl or an optionally substituted heterocycle.

Dérivés d'acide 4,5-dihydro-[1H]-benz[g]indazole-3-carboxylique représentés par la formule (I) ou leurs sels, présentant un antagonisme excellent par rapport aux récepteurs d'endothéline et efficaces en tant qu'agents prophylactiques ou thérapeutiques pour l'hypertension, l'angine de poitrine, l'infarctus du myocarde, l'infarctus cérébral, les contractions cérébrovasculaires, l'insuffisance rénale, le dysfonctionnement hépatique, l'athérosclérose, la constriction post ACTP etc., dans laquelle Ar représente aryle éventuellement substitué; R?1¿ représente hydrogène, alkyle inférieur éventuellement substitué, aryle éventuellement substitué, cycloalkyl éventuellement substitué ou un composé hétérocyclique éventuellement substitué.

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