4,5-dihydro-2-substituted-6-(pyridinyl)-3(2h)-...

Details 4,5-dihydro-2-substituted-6-(pyridinyl)-3(2h)-... 4,5-dihydro-2-substituted-6-(pyridinyl)-3(2h)-...

C - Chemistry, Metallurgy

07

D

260/264.7

C07D 401/04 (2006.01) C07D 213/04 (2006.01) C07D 213/57 (2006.01)

Patent

CA 1166255

ABSTRACT OF THE DISCLOSURE 2-R-4,5-dihydro-4-R'-6-PY-3(2H)-pyridazinones (I) or salts thereof, which are useful as cardiotonics, where R is lower-alkyl, R' is hydrogen or lower-alkyl, and PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents, are prepared by reacting 4-oxo-4-PY-2-R'- butanenitrile with an N-R-hydrazine salt of a strong inorganic acid or organic sulfonic acid or by reacting a lower-alkyl 4-oxo- 4-PY-2-R'-butanoate or lower-alkyl 4-(sN)-4-cyano-4-PY-2-R'- butanoate with N-R-hydrazine where BW is 4-morpholinyl, 1- piperidinyl or l-pyrrolidinyl. Also shown are: a) cardiotonic compositions and a method for increasing cardiac contractility using said compounds or salts where R is lower-alkyl b) the use of I as intermediates in preparing the corresponding 2- R-4-R'-6-PY-3(2H)-pyridazinones; and, c) the preparation of said lower alkyl 4-(BN)-4-cyano-4-PY-2-R'-butanoates.

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