4-5-dihydro-4-oxo-2-¬2-trans-phenylcyclopropyl)...

Details 4-5-dihydro-4-oxo-2-¬2-trans-phenylcyclopropyl)... 4-5-dihydro-4-oxo-2-¬2-trans-phenylcyclopropyl)...

C - Chemistry, Metallurgy

07

D

260/361.1

C07D 307/68 (2006.01)

Patent

CA 1240687

ABSTRACT Antimicrobial 4,5-dihydro-4-oxo-2-((2-trans-phenylcyclopropyl) amino]-3-furancarboxylic acids and derivatives thereof which have the formula: Image where R is selected from hydroxy, lower alkoxy, and O-alkali metal; and where R1 is selected from phenyl and phenyl substituted with lower alkyl and/or halogen. The invention further provides a process for the preparation of these compounds, characterized by preparing the ester derivatives, where R is lower alkoxy, by a base catalyzed cyclocondensation of a lower alkyl-4- chloroacetoacetate with a trans-phenylcyclopropyl isocyanate of the formula: Image where R1 is as defined above, preparing the free acid, where R is hydroxy, by alkaline hydrolysis of the ester derivatives, and preparing the salt derivatives, where R is O-alkali metal, by reaction of the free acid with an alkali metal carbonate.

488712

Affiliated with

Also associated with

Rating

4-5-dihydro-4-oxo-2-¬2-trans-phenylcyclopropyl)... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 4-5-dihydro-4-oxo-2-¬2-trans-phenylcyclopropyl)..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4-5-dihydro-4-oxo-2-¬2-trans-phenylcyclopropyl)... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1229126