4,5-dihydro-6-¬2-¬4-(1h-imidazol-1-yl)phenyl|-...

Details 4,5-dihydro-6-¬2-¬4-(1h-imidazol-1-yl)phenyl|-... 4,5-dihydro-6-¬2-¬4-(1h-imidazol-1-yl)phenyl|-...

C - Chemistry, Metallurgy

07

D

167/224, 260/264

C07D 403/10 (2006.01) A61K 31/50 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1244828

DOZ-1 ABSTRACT 4,5-Dihydro-6-[2-[4-[1H-imidazol-1-yl)phenyl] alkylenyl or alkylene-3(2H)-pyridazinones and related compounds and pharmaceutically acceptable acid addition salts thereof are useful as cardiotonic and antihypertensive agents. The above compounds cause a significant increase in myocardial contractility in the dog and also cause a decrease in blood pressure in the spontaneously hypertensive rat. The compounds are produced by reacting the appropriate .gamma.-oxobutanoic acid with a suitably substituted hydrazine to provide 4,5- dihydro-6-[4-[imidazolylphenyl]-alkenylene or alkylene-3(2H)-pyridazinones which may be oxidized to 6-[4-[imidazolylphenyl]alkenylene or alkylene- 3(2H)-pyridazinones.

468522

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