4,5-dihydro-6-¬(substituted)-lh-imidazol-4-yl or 5-...

Details 4,5-dihydro-6-¬(substituted)-lh-imidazol-4-yl or 5-... 4,5-dihydro-6-¬(substituted)-lh-imidazol-4-yl or 5-...

C - Chemistry, Metallurgy

07

D

260/264.7

C07D 401/14 (2006.01) C07D 233/54 (2006.01) C07D 403/04 (2006.01)

Patent

CA 1210765

ABSTRACT 4,5-Dihydro-6-[(substituted)-1H-imidazol-4-yl or 5-yl]-3(2H)-pyridazinones 6-[(substituted)-1H- imidazol-4-yl or 5-yl]-3(2H3-pyridazinones and pharmaceutically acceptable acid addition salts thereof are useful as cardiotonic and antihypertensive agents. The above compounds cause a significant increase in myocardial contractility in the dog and also cause a decrease in blood pressure in the spontaneously hypertensive rat. The compounds are produced by reacting the appropriate y-oxo-imidazolebutanoic acid with a suitably substituted hydrazine to provide 4,5-dihydro-6-(substituted)imidazolyl-3(2H)-pyrida- zinones which are oxidized to 6-(substituted)imidazolyl- 3(2H)-pyridazinones.

447538

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