4,5-dihydro and 4,5,6,7-tetrahydropyrazolo-[1,5-a] pyrimidines

Details 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo-[1,5-a] pyrimidines 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo-[1,5-a] pyrimidines

C - Chemistry, Metallurgy

07

D

167/220, 260/242

C07D 487/04 (2006.01) A61K 31/505 (2006.01)

Patent

CA 1305703

30,163 4,5-DIHYDRO AND 4,5,6,7- TETRAHYDROPYRAZOLO[1,5-A]- PYRIMIDINES ABSTRACT OF THE INVENTION Novel compounds having tbe following structural formula: Image Ia or Ib wherein --- may represent the presence of a double bond between the C6 and C7 position, Ia, or the absence of a double bond between the C6 and C7 position, Ib; R1 is selected from the group consisting essentially of hydrogen, bromo, chloro, carbamoyl, carboxyl, carboxyalkoxyl where alkoxyl is (C1-C3), cyano, -CO-CF3, COONa, Image , -CO-C(CH3)3, and Image where X is hydrogen, cyano, halogen and nitro; R2, R4 and R5 may be hydrogen and lower alkyl(C1-C3); R3 is hydrogen, alkyl(C1-C3), Image where R7 and R8 may be the same or different and are selected from the group consisting essentially of hydrogen, halogen, alkyl(C1-C3), nitro, alkoxy(C1-C3), trifluoro- methyl, acetylamino or N-alkylacetylamino where alkyl is (C1-C3), and R3 may also be selected from a monovalent radical selected from the class consisting essentially of 3-thienyl, 2-pyridinyl, 3-pyridinyl and 4-pyridinyl, either of said pyridinyl radicals being optionally substituted with an alkyl radical R9, where alkyl is (C1-C4), and the structures of the monovalent 2-pyridinyl, 3-pyridinyl and 4-pyridinyl moieties are depicted respectively as: Image and Image ; R6 is hydrogen or alkyl- (C1-C3); pharmaceutical compositions of matter containing the above-defined compounds; methods for using the com- pounds as anxiolytic agents, antihypertensive agents or antidepressant agent in mammals; processes for the preparation of the compounds.

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