4,5-dihydro-imidazole as p2x7 ion channel blockers

Details 4,5-dihydro-imidazole as p2x7 ion channel blockers 4,5-dihydro-imidazole as p2x7 ion channel blockers

C - Chemistry, Metallurgy

07

D

C07D 233/48 (2006.01) A61K 31/4164 (2006.01) A61K 31/4168 (2006.01) A61K 31/4184 (2006.01) C07D 233/20 (2006.01) C07D 233/22 (2006.01) C07D 233/24 (2006.01) C07D 233/42 (2006.01) C07D 233/46 (2006.01) C07D 235/30 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 409/10 (2006.01)

Patent

CA 2532910

The present invention relates to a novel series of 4,5-diphenyl-2-amino-4,5- dihydro-imidazole derivatives of the formula (II): wherein R, R1, R2, R3, R4, R5, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are P2X7 ion channel blockers and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases having an inflammatory component, including inflammatory bowel disease, rheumatoid arthritis and disease conditions associated with the central nervous system, such as stroke, Alzheimer's disease, etc.

Cette invention se rapporte à une nouvelle série de dérivés de 4,5-diphényl-2-amino-4,5-dihydro-imidazole représentés par la formule (II): dans laquelle R, R¿1?, R¿2?, R¿3?, R¿4?, R¿5?, X et Y sont tels que définis dans les pièces descriptives de la demande. Cette invention concerne également des procédés de fabrication de ces composés. Ces composés constituent des antagonistes des canaux ioniques P2X7 et ils sont par conséquent utiles comme agents pharmaceutiques, notamment dans le traitement et/ou la prévention d'une grande variété de maladies ayant une composante inflammatoire, telles que la maladie intestinale inflammatoire, la polyarthrite rhumatoïde et des états pathologiques associés au système nerveux central, tels que attaques, maladie d'Alzheimer, etc.

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