4,5-dihydro-oxazol-2-yl amine derivatives

Details 4,5-dihydro-oxazol-2-yl amine derivatives 4,5-dihydro-oxazol-2-yl amine derivatives

C - Chemistry, Metallurgy

07

D

C07D 263/28 (2006.01) A61K 31/422 (2006.01) A61P 25/28 (2006.01) C07D 413/10 (2006.01)

Patent

CA 2712228

The present invention relates to a compounds of formula I or a pharmaceutically active acid addition salts thereof. It has been found that the present compounds have Asp2 (.beta.-sccretasc, BACE 1 or Mcmapsin-2) inhibitory activity and that the compounds may therefore be used in the treatment of diseases characterised by elevated .beta.-amyloid levels or .beta.-amyloid deposits, particularly Alzheimer's disease.

La présente invention porte sur des composés de formule I ou des sels pharmaceutiquement actifs d'addition avec les acides de ces composés. Il a été découvert que les présents composés ont une activité inhibitrice de Asp2 (ß-sécrétase, BACE 1 ou memapsine-2) et que les composés peuvent donc être utilisés dans le traitement de maladies caractérisées par des taux élevés de ß-amyloïde ou des dépôts élevés de ß-amyloïde, en particulier la maladie d'Alzheimer.

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