4,5-pyrazinoxindoles as protein kinase inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 487/04 (2006.01) A61K 31/4985 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2354402

4,5-pyrazinoxindoles having formula (I), inhibit or modulate protein kinases, in particular JNK protein kinases and are useful as anti-inflammatory agents, particularly in the treatment of rheumatoid arthritis.

L'invention concerne les 4,5-pyrazinoxindoles représentés par la formule (I), inhibant ou modulant les protéines kinases, en particulier les protéines kinases JNK, et utiles comme agents anti-inflammatoires, en particulier dans le traitement de la polyarthrite rhumatoïde.

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