C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4375 (2006.01)
Patent
CA 2608362
The present invention provides compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, m and n are defined as described herein. The invention also provides methods of making the compounds of formula (I), and methods of treating inflammatory diseases, such as rheumatoid arthritis, in a mammal comprising administering a therapeutically effective amount of a compound of formula (I) to the mammal.
L'invention concerne des composés de formule (I) et des sels acceptables sur le plan pharmaceutique de ceux-ci, dans laquelle R1, R2, R3, R4, R5, R6, m et n sont tels que définis dans la description. L'invention concerne également des procédés de fabrication des composés de formule (I) et des procédés permettant de traiter des maladies inflammatoires, telles que la polyarthrite rhumatoïde, chez un mammifère et consistant à administrer une quantité efficace sur le plan thérapeutique d'un composé de formule (I) au mammifère.
Cuozzo John William
Gavrin Lori Krim
Gopalsamy Ariamala
Green Neal Jeffrey
Hu Yonghan
Torys Llp
Wyeth
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