4-6-diphenyl pyridine derivatives as antiinflammatory agents

Details 4-6-diphenyl pyridine derivatives as antiinflammatory agents 4-6-diphenyl pyridine derivatives as antiinflammatory agents

C - Chemistry, Metallurgy

07

D

C07D 213/85 (2006.01) A61K 31/44 (2006.01) A61K 31/4545 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61P 29/00 (2006.01) C07D 213/73 (2006.01) C07D 213/80 (2006.01) C07D 213/82 (2006.01) C07D 401/10 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2430354

4-aryl pyrimidine compounds of general formula and salts thereof:wherein X is CH or N; R1 is hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, etc.; R2 is hydrogen, halogen, etc.; R3 is hydrogen, hydroxy, halogen, amino, etc.; R4 is hydroxy, amino, carboxy, etc. or R3 and R4 together form a ring; R5 is hydrogen, carbamoyl, cyano, carboxy, C1-16 alkoxycarbonyl, etc. and R6 is amino or C1-16 alkanoylamino or R5 and R6 together form a ring. The compounds (I) or the salts thereof have an excellent anti-inflammatory activity and act as inhibitors of IKK-.beta. and thus inhibit nuclear factor kappa B(NF-KB).

L'invention concerne des composés de 4-aryle pyrimidine de formule générale (I) et des sels desdits composés. Dans cette formule, X est CH ou N, R?1¿ est hydrogène, halogène, alkyle C¿1-6?, alcoxy C¿1-6?, etc., R?2¿ est hydrogène, halogène,, R?3¿ est hydrogène, hydroxy, halogène, amino, etc., R?4¿ est hydroxy, amino, carboxy, etc., R?4¿ est hydroxy, amino, carboxy, etc., R?5¿ est hydrogène, carbamoyle, cyano, carboxy, alcoxycarbonyle C¿1-6?, etc., et R?6¿ est amino ou alcanoylamino C¿1-6?. Les composés (I) ou les sels desdits composés présentent notamment une excellente activité anti-inflammatoire.

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