[4-(6-fluoro-7-methylamino-2,4-dioxo-1,4-dihydro-2h-quinazol...

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 409/12 (2006.01) A61K 31/517 (2006.01) A61P 7/02 (2006.01)

Patent

CA 2742601

The present invention provides novel sulfonylurea salts of a salt of formula (I) \ and polymorph forms thereof. The compounds in their various forms are effective platelet ADP receptor inhibitors and may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also provides a method for preparing such compounds and forms and for preventing or treating thrombosis and thrombosis related conditions in a mammal comprising the step of administering a therapeutically effective amount of a salt of formula (I) or a pharmaceutically acceptable form thereof.

La présente invention concerne de nouveaux sels de sulfonylurée d'un sel de formule (I) et des formes polymorphes de ces sels. Les composés sous leurs diverses formes sont des inhibiteurs du récepteur de l'ADP plaquettaire efficaces et peuvent être utilisés dans diverses compositions pharmaceutiques, et sont particulièrement efficaces en vue de la prévention et/ou du traitement de maladies cardio-vasculaires, en particulier ces maladies apparentées à une thrombose. L'invention concerne également un procédé de préparation de ces composés et ces formes et de prévention et de traitement d'une thrombose et des états associés à une thrombose chez un mammifère qui comprend l'étape consistant à administrer une quantité thérapeutiquement efficace d'un sel de formule (I) ou d'une forme pharmaceutiquement acceptable de celui-ci.

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