4-, 6- o 7-hydroxyindoles having n-oxide groups and the use...

Details 4-, 6- o 7-hydroxyindoles having n-oxide groups and the use... 4-, 6- o 7-hydroxyindoles having n-oxide groups and the use...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4439 (2006.01) A61P 11/00 (2006.01)

Patent

CA 2523048

The invention relates to substituted 4-, 6- or 7-hydroxyindoles having N-oxide groups of formula (I), a method for the production thereof, pharmaceutical preparations comprising said compounds and the pharmaceutical use of said compounds which are inhibitors of phosphodiesterase 4, as active substances in the treatment of diseases which can be influenced by said inventive compounds by means of an inhibition of phosphodiesterase 4 activity, especially in immunocompetent cells (for example, macrophages and lymphocytes).

L'invention concerne des 4-, 6- ou 7-hydroxyindoles substitués à groupes N-oxyde de formule (I), des procédés de production de ces composés, des préparations pharmaceutiques contenant ces composés ainsi que l'utilisation pharmaceutique de ces composés, inhibiteurs de la phosphodiestérase 4, comme principes actifs dans le traitement de maladies nécessitant une inhibition de l'activité de la phosphodiestérase 4 en particulier dans des cellules immunocompétentes (p. ex. macrophages et lymphocytes) par les composés de la présente invention.

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