4-'7-halo-2-quino(xa-)linyloxy!phenoxy-propionic acid...

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 215/22 (2006.01) A61K 31/47 (2006.01) A61K 31/498 (2006.01) A61P 35/00 (2006.01) C07D 215/227 (2006.01) C07D 241/44 (2006.01)

Patent

CA 2491612

The invention provides compounds of the formula (I): wherein A, X, Y, and Z are as defined in the specification. The compounds are effective anti-tumor agents. The invention also provides pharmaceutical compositions comprising a compound of the above formula or a salt thereof, intermediates useful for preparing a compound of the above formula, and therapeutic methods comprising administering a compound of the above formula or a salt thereof to a mammal in need thereof.

Cette invention se rapporte à des composés représentés par la formule (I), où A, X, Y et Z sont tels que définis dans les pièces descriptives de la demande. Ces composés constituent des agents antitumoraux efficaces. Cette invention concerne également des compositions pharmaceutiques comprenant un composé représenté par cette formule ou un sel de ce composé, des intermédiaires permettant de préparer un composé représenté par cette formule, et des procédés thérapeutiques consistant à administrer un composant représenté par cette formule ou un sel de ce composé à un mammifère nécessitant un tel traitement.

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