C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/06 (2006.01) A61K 31/40 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01)
Patent
CA 2354873
Novel 4-alkenyl- and 4-alkynyl oxindoles having formulas (I) and (II) and the pharmaceutically acceptable salts thereof, wherein R1, R2, R3, a, b, and X are as defined herein inhibit cyclin-dependent kinases (CDKs), in particular CDK2 and are useful as anti-proliferative agents in the treatment or control of cell proliferative disorders, in particular breast and colon tumors.
La présente invention concerne de nouveaux 4-alcényl- et 4-alcynyl oxindoles représentés par les formules (I) et (II) et leurs sels acceptables sur le plan pharmaceutique. Dans cette formule, R?1¿, R?2¿, R?3¿, a, b, et X tels que définis dans cette invention inhibent les kinases dépendantes des cyclines (CDK), en particulier la CDK2, et sont utilisés comme agents anti-prolifératifs dans le traitement ou le contrôle des troubles liées à la prolifération cellulaire, en particulier le cancer mammaire et le cancer du côlon.
Chen Yi
Corbett Wendy Lea
Dermatakis Apostolos
Liu Jin-Jun
Luk Kin-Chun
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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