C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/219, 260/242
C07D 471/04 (2006.01) A61K 31/505 (2006.01)
Patent
CA 1257261
Abstract The invention concerns 4-alkoxy-pyrido [2,3-d] pyrimidine derivatives of the general formula I Image (I) wherein R1 represents an unsubstituted or substituted aromatic or heteroaromatic ring, R2 a nitril group, a carboxyl group or an alkoxycarbo- nyl residue with up to 6 carbon atoms, R3 a straight-chained or branched alkyl group with up to 4 carbon atoms, or an amino group, and R4 a straight-chained or branched alkyl group with up to 4 carbon atoms, the pharmacologically safe salts thereof, as well as processes for their preparation. For reason of their vasospasmolytic effects the com- pounds I are mainly indicated for the treatment of cerebral, cardiac and peripheral vascular diseases such as myocardiac ischemia, cerebral infarction, pulmonary thromboses, as well as in cases of arteriosclerosis and other stenotic disorders. They are therefore valuable agents for combating cardiovascular mortality. Another subject-matter of the present invention is the use of 4-alkoxy-pyrido [2,3] pyrimidine derivatives of the ge- neral formula I for the treatment of vascular diseases and pharmaceutical compositions containing the new compounds.
493181
Fritschi Edgar
Hartenstein Johannes
Kleinschroth Jurgen
Mannhardt Karl
Osswald Hartmut
Godecke Aktiengesellschaft
Smart & Biggar
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