4-alkoxypyridazine derivatives as fast dissociating dopamine...

Details 4-alkoxypyridazine derivatives as fast dissociating dopamine... 4-alkoxypyridazine derivatives as fast dissociating dopamine...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/501 (2006.01) A61P 25/18 (2006.01)

Patent

CA 2683111

The present invention relates to (1-benzyl-piperidin-4-yl) - (4-alkoxy-pyridazin-3-yl) - amines of formula (I) that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects.

L'invention concerne des (1-benzyl-pipéridine-4-yl)-(4-alkoxy-pyridazine-3-yl)- amines représentés par la formule (I) qui sont des antagonistes du récepteur 2 de la dopamine à dissociation rapide, des procédés d'obtention de ces composés et des compositions pharmaceutiques contenant lesdits composés en tant que principe actif. Ces composés conviennent pour le traitement ou la prévention des troubles du système nerveux central, notamment de la schizophrénie, grâce à leur action antipsychotique sans effets moteurs secondaires.

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