4-alkyl-1,4-dihydropyridines with paf-acether-antagonist...

Details 4-alkyl-1,4-dihydropyridines with paf-acether-antagonist... 4-alkyl-1,4-dihydropyridines with paf-acether-antagonist...

C - Chemistry, Metallurgy

07

D

167/228, 260/291

C07D 211/90 (2006.01) A61K 31/435 (2006.01) C07D 405/12 (2006.01)

Patent

CA 1332838

4-alkyl-1,4-dihyropyridines, with PAF-acether-antagonist activity, of formula (I) wherein R is saturated C1-C4, R' is saturated C1-C6 alkyl which may be interrupted by an oxygen atom, or 2-tetrahydrofurfuryl and R2 is saturated C1-C4 or phenyl, the compound wherein R is methyl, R' is ethyl and R2 is phenyl remain excluded, are described. The compounds (I) are prepared by: (a) reaction of (II) with (III); (b) reaction of (IV) with (V); (c) reaction of (VI) with (III) and with (VII); (d) reaction of (VIII) with (V) and with (VII); or (e) reaction of (VIII) with (VI) and with (VII) in the presence of ammonia. The compounds (I) are useful due to their antagonist activity of the platelet activating factor. Image Image II I Image III Image IV Image V CH3-CO-CH2-COOR' VI R-CHO VII CH3-CO-CH2-COO-(CH2)2-S-R2 VIII

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