4-amidino chroman and 4-amidino pyrano (3,2-c) pyridine...

Details 4-amidino chroman and 4-amidino pyrano (3,2-c) pyridine... 4-amidino chroman and 4-amidino pyrano (3,2-c) pyridine...

C - Chemistry, Metallurgy

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C07D 405/04 (2006.01) A61K 31/44 (2006.01) A61K 31/505 (2006.01) C07D 213/72 (2006.01) C07D 239/42 (2006.01) C07D 491/04 (2006.01) C07D 491/052 (2006.01)

Patent

CA 2029278

IN THE CANADIAN PATENT AND TRADEMARK OFFICE PATENT APPLICATION Entitled : 4-amidino chroman and 4-amidino pyrano (3,2-c) pyridine derivativés, a process for their preparatjon and pharmaceutical compositions containing them. in the names of : Georges GARCIA Patrick GAUTIER Dino NISATO Richard ROUX Assignee : SANOFI ABSTRACT OF THE DISCLOSURE The present invention deals with 4-amidino chroman and 4-amidino pyrano (3,2-c) pyridine derivatives, a process for their preparation and pharmaceutical compositions containing them. Said derivatives have antihypertensive and antiarythmic activities. They respond to formula (I) Image in which : . A + B = -CH=CH-CH=N- ou -CH=CR4-CR5=CH-; . X = N, N ? 0, C-Z ; . R1 = H, CN, NO2, C1-C4 alkyl, OH, C1-C4 alcoxy, CF3CO-, CH3-S02-, ?-SO2-; . R2 = H ; . R3 = OH ou OCOCH3 ou R2 + R3 = double bond.

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