4-amino...

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C - Chemistry, Metallurgy

07

D

C07D 215/42 (2006.01) A61K 31/4706 (2006.01) A61K 31/4709 (2006.01) A61P 3/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2581462

4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL- cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans. Formula (I).

Composés de 4-amino substitué-2-substitué-1,2,3,4-tétrahydroquinoline de formule (I), compositions pharmaceutiques contenant ces composés et utilisation de ces composés pour élever certains taux plasmatiques de lipides, dont le cholestérol à lipoprotéines de haute densité (HDL), et pour abaisser certains autres taux plasmatiques de lipides, tels que le cholestérol à lipoprotéines de basse densité (LDL) et les triglycérides, et par conséquent pour traiter des maladies qui sont aggravées par des taux bas de cholestérol HDL et / ou par des taux élevés de cholestérol LDL et de triglycérides, telles que l'athérosclérose et les maladies cardio-vasculaires chez certains mammifères, dont l'homme.

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