4-amino-3-(imidazolyl)-pyrazolo[3,4-d]pyrimidines

Details 4-amino-3-(imidazolyl)-pyrazolo[3,4-d]pyrimidines 4-amino-3-(imidazolyl)-pyrazolo[3,4-d]pyrimidines

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01)

Patent

CA 2736362

Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are 4-amino-3-imidazoyl-pyrazolo[3,4-d]pyrimidine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.

La présente invention concerne des composés qui constituent de puissants antagonistes du récepteur CCR1, et qui présentent in vivo une activité anti-inflammatoire. Ces composés dérivés de 4-amino-3-(imidazolyl)-pyrazolo[3,4-d]pyrimidines, conviennent particulièrement pour l'élaboration de compositions pharmaceutiques, pour le traitement de maladies médiées par CCR1, et comme témoins pour l'identification d'antagonistes compétitifs de CCR1.

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