4-amino-4-oxobutanoyl peptides as inhibitors of viral...

Details 4-amino-4-oxobutanoyl peptides as inhibitors of viral... 4-amino-4-oxobutanoyl peptides as inhibitors of viral...

C - Chemistry, Metallurgy

07

K

C07K 5/02 (2006.01) A61K 38/00 (2006.01) C07K 5/06 (2006.01) C07K 5/08 (2006.01)

Patent

CA 2657618

The invention rovides 4-amino-4-oxobutanoyl peptide compounds of Formula I (I) and the pharmaceutically salts and hydrates thereof. The variables R1-R9, R16, R18 R19, n, M,, n, M,, and Z are defined herein. Certain compounds of Formula I are useful as antiviral agents. Certain 4-amino-4-oxobutanoyl peptide compounds disclosed herein are potent and/ or selective inhibitors of viral replication, particularly Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more 4-amino-4-oxobutanoyl peptide compounds and one or more pharmaceutically acceptable carriers. Such pharmaceutical compositions may contain 4-amino-4-oxobutanoyl peptide compound as the only active agent or may contain a combination of 4-amino-4-oxobutanoyl peptide containing peptides compound and one or more other pharmaceutically active agents. The invention also provides methods for treating viral infections, including Hepatitis C infections, in mammals.

L'invention concerne des composés consistant en 4-amino-4-oxobutanoyl peptides représentés par la Formule I (I) et les sels et hydrates pharmaceutiquement acceptables de ces composés. Les variables R1-R9, R16, R18, R19, n, M,, n, M'' et Z sont définies ici. Certains composés représentés par la Formule I sont utiles en tant qu'agents antiviraux. Certains composés 4-amino-4-oxobutanoyl peptides décrits ici sont des inhibiteurs puissants et/ou sélectifs de la réplication virale, en particulier de la réplication du virus de l'hépatite C. L'invention concerne également des compositions pharmaceutiques contenant un ou plusieurs composés 4-amino-4-oxobutanoyl peptides et un ou plusieurs supports pharmaceutiquement acceptables. De telles compositions pharmaceutiques peuvent contenir le composé 4-amino-4-oxobutanoyl peptide en tant que seul agent actif ou peuvent contenir une combinaison de peptides contenant le 4-amino-4-oxobutanoyl peptide et un ou plusieurs autres agents pharmaceutiquement actifs. L'invention concerne également des procédés pour le traitement d'infections virales, dont les infections de l'hépatite C, chez les mammifères.

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