4-amino-4-steroids and their use as 5.alpha.-reductase...

Details 4-amino-4-steroids and their use as 5.alpha.-reductase... 4-amino-4-steroids and their use as 5.alpha.-reductase...

C - Chemistry, Metallurgy

07

J

C07J 41/00 (2006.01) A61K 31/56 (2006.01)

Patent

CA 2048242

The present invention relates to 4-amino-.DELTA.4-steroids of the formula: (see formula I) which are useful as inhibitors of 5.alpha.-reductase, for example in treating a patient afflicted with a dihydrotestosterone - mediated disease or condition or for treating benign prostatic hypertrophy in a patient. The compounds are prepared by the reaction of an appropriate 4-azido steroid with triphenylphosphine in an aqueous inert solvent with heating.

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