4-amino-6-(pyridinyl)-3(2h)-pyridazinones, preparation and...

Details 4-amino-6-(pyridinyl)-3(2h)-pyridazinones, preparation and... 4-amino-6-(pyridinyl)-3(2h)-pyridazinones, preparation and...

C - Chemistry, Metallurgy

07

D

260/264.7

C07D 401/04 (2006.01) C07D 213/04 (2006.01) C07D 213/55 (2006.01)

Patent

CA 1166253

D.N. 3698 ABSTRACT OF THE DISCLOSURE 4-Amino-2-R-6-PY-3(2H)-pyridazinones (I) or salts thereof, which are useful as caraiotonics, where R is hydrogen, lower-alkyl or lower-hydroxyalkyl, and PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower- alkyl substituents are prepared by: a) reaction of 2-R-6- PY-3(2H)-pyridazinone (II) with hydrazine; b) conversion from 2,3-dihydro-2-R-3-oxo-6-PY-4-pyridazinecarboxamide (III); or, c) conversion form 2,3-dihydro-2-R-3-oxo-6-PY-4- pyridazinecarboxylic acid hydrazide (IV). Also shown are. the use of I or salts as cardiotonic agents; and, the preparation of intermediates.

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